Weight Loss Medication Microdosing Risks Infection, Contamination, and Lipohypertrophy

A rising trend among weight loss medication users involves microdosing—taking smaller doses than prescribed—to extend the life of injection pens. While this may seem economical, experts warn it could lead to serious health risks including infections, contamination, and the development of lipohypertrophy.

Jason Murphy, Head of Pharmacy and weight loss expert at Chemist4U, cautions against this practice. “Microdosing often results in increased injections and the temptation to reuse needles, which presents significant dangers,” he explains.

Reusing needles causes the tips to dull, increasing pain, bruising, and inflammation at injection sites. Over time, this can lead to persistent tissue irritation, making injections uncomfortable and challenging. Additionally, residue buildup can block needles, affecting medication delivery and causing inconsistent treatment outcomes.

Of greater concern is bacterial contamination from needle reuse. “A single reuse can introduce harmful bacteria beneath the skin, heightening the risk of infections, redness, swelling, and potentially serious medical complications,” Murphy warns. Needles are sterile only before use; subsequent injections with the same needle create pathways for bacteria to enter the body, endangering health.

Furthermore, frequent injections in the same area, even with new needles, can cause lipohypertrophy—lumps of scarred tissue under the skin that impair medication absorption. Proper rotation of injection sites and use of new needles each time are essential to prevent this condition.

Murphy emphasizes the importance of adhering strictly to prescribed dosages. “Taking less than the recommended dose may worsen side effects and poses unknown risks. Even minor dose variations can impact both the safety and effectiveness of treatment.”

For optimal results and to avoid complications, patients should follow medical instructions precisely and avoid the microdosing trend.